A BallMillingEnabled Reformatsky Reaction Cao 2019
The solutionbased reaction in dry THF and under nitrogen atmosphere at 50 #176;C with either zinc flakes or granular zinc (no additive used) resulted in low yields of 7 and 4 %, respectively (Scheme 4 B), whereas under ballmilling conditions without any solvent, inert gas, or additive (Table 2), the reaction proceeded smoothly in 2 h and all forms of zinc explored were effective for this